[laquo]Clinically silent[raquo] somatotropinoma
نویسندگان
چکیده
منابع مشابه
A meiotic recombination in a new isolated familial somatotropinoma kindred.
We report here the genetic findings of a new isolated familial somatotropinoma (IFS) kindred in which the mother (subject I:2) and one daughter (subject II:2) are affected; their ages at diagnosis were 25 and 14 years respectively. Additionally, patient I:2 developed virilization due to an androgen-secreting adrenocortical mass, presenting clinical and molecular features of sporadic adrenal car...
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Thyroid stimulating hormone (TSH) secreting pituitary adenomas are rare tumors manifested as hyperthyroidism with goiter in the presence of elevated TSH. We present a case with pituitary adenoma secreting both TSH and growth hormone (GH) with the prominent clinical findings of hyperthyroidism but without clinical findings of acromegaly. Pituitary magnetic resonance imaging revealed a macroadeno...
متن کاملTiming of Surgical Approach on Patients with Somatotropinoma and Differentiated Thyroid Cancer
Acromegaly is a rare chronic, progressive disease caused by the increased secretion of growth hormone (GH) and subsequently insulin-like growth factor 1 (IGF-1). Benign thyroid overgrowth is a common phenomenon in this pathology, but some studies revealed that acromegaly is associated with an increase in the prevalence of malignant thyroid nodules. We present two cases of acromegaly associated ...
متن کاملExpression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues
The expression of somatostatin receptor subtypes (SSTRs) in pituitary growth hormone- (GH-) secreting adenomas may predict the response to somatostatin analogues (SSA). Our aim was to evaluate the value of the immunohistochemical (IHC) scores of 2 subtypes, SSTR2 and SSTR5, in predicting the short-term efficacy of SSA therapy in patients with active acromegaly. Ninety-three newly diagnosed acro...
متن کاملGenome-wide scan identifies novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma.
Isolated familial somatotropinoma (IFS) accounts for 18% of familial isolated pituitary adenoma (FIPA) cases. Recently, germline mutations of the aryl hydrocarbon receptor-interacting protein gene (AIP) have been found in families with pituitary adenoma predisposition, FIPA, and IFS. In this study, we investigate the AIP mutation status and perform a genome-wide scan to search for the modifier ...
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ژورنال
عنوان ژورنال: Endocrine Abstracts
سال: 2016
ISSN: 1479-6848
DOI: 10.1530/endoabs.41.ep267